The development of targeted therapies (BRAF/MEK inhibitors) and immunotherapy have had a major impact on the treatment of melanoma.However, the majority of patients with advanced melanomas succumb to their disease.The mechanisms of resistance to both targeted therapies and immunotherapies are numerous and have been well-described.These include the

The subpopulation of the bowhead whale Balaena Drugs mysticetus in the East Greenland-Svalbard-Barents Sea is endangered and until recently was believed to number in the tens.Recent studies have suggested that this subpopulation appears to be increasing.Here, we report on unusual aggregations of bowhead whales within the Fram Strait.We present oppo

The aim of this work was to develop a process for the salt pepper removal of Sn, Sb and As from anode slime out of copper refinery to disburden a subsequent pyrometallurgical processing for precious metals refinement.For this reason, a detailed literature survey was conducted, followed by a characterization to find the present compounds/alloys and

Abstract Background At the onset of the COVID-19 pandemic, a local consortium in Uganda set up a telehealth approach that aimed to educate 3,500 Community Health Workers (CHW) in rural areas about COVID-19, help them identify, refer and care for potential COVID-19 cases, and support them in continuing their regular community health work.The aim of

Fibrous membranes offer broad opportunities to deploy immobilized enzymes in new reactor and application designs, including multiphase continuous flow-through reactions.Enzyme immobilization is a technology strategy that Lug Nut Covers (All Styles and Sizes) simplifies the separation of otherwise soluble catalytic proteins from liquid reaction medi